The expertise, knowledge and know how of our scientists

PROVAXS offers access to a network of laboratories at Ghent University with a focus on infectious diseases and immunity that unite their expertise for the development of innovative vaccines, targeted therapeutics, feed additives and diagnostics.

We offer in depth academic expertise and research capacity on selected animal pathogens and the interaction with their host.

Academic and regulatory expertise
  • Know how of professors and academic scientists who perform breakthrough research in their field of expertise
  • Tailor-made study design and protocol
  • In depth data evaluation and interpretation of results by academic experts
  • Ready-to-use results and reports
  • Experience in vaccine development
  • Contribution to WAAVP and VICH guidelines
  • Member of EMA advisory board
Various challenge models and in vitro models
  • Efficacy studies according to WAAVP and VICH guidelines (including early evaluation of efficacy, comparative studies and studies for registration purposes)
  • Use of highly characterised challenge strains in reliable and reproducible models
  • Classical infection and seeder-models
  • Pathogenesis and vaccination-challenge studies
  • Various in vitro models to quantify virus replication and/or determine cell tropism e.g. polarized nasal explants, macrophages/monocytes, cardiomyocytes
  • in vitro: MIC, transwell insert model, cell invasion test,…
  • in vitro/in vivo: intestinal loop model (pig), caecal loop model (chicken)
  • A panel of in vitro and in vivo tests to determine innate (NK cells, macrophages, neutrophils), humoral (antibodies, antibody secreting cells) and cellular (lymphocyte identification, cytokine responses, dendritic cells) immune responses
Experienced BSL2/3 laboratories and animal facilities
  • Sample analysis in a broad diagnostic context (bacteriological, virological, parasitological )
  • Quantification of pathogenic load upon infection and/or vaccination-challenge (e.g. organs, excretions, blood)
  • Quantification of serological responses to vaccination and infection
  • Necropsy and histopathology
  • Genetic sequencing and analysis
Field studies
  • Networking with farmers and farm organisations
  • Efficacy studies under field conditions combined with monitoring of effects on the productivity of the animals
  • Collection of recent local field isolates

Our focus is on animal health but some technologies and know how can be used for or translated to applications in human medicine.