Permissive cells for PRRSV production – LICENSED

• The PRRS-virus can infect the cells via the natural route due to the presence of both sialoadhesin and CD163, the two receptors that are essential for binding, internalization and multiplication
• On average Sn+CD163 cells can produce PRRSV at titers of 1 log higher than in MARC-cells
• Multiple PRRSV-strains can be grown on the Sn+CD163 cells which offers flexibility in production (e.g. for multistrain registration)
• The cells can be used for QC or in a potency test to demonstrate structural and functional integrity of the PRRSV as long as it can bind and internalize
• Since the PRRS-virus can follow its natural route of infection no or little virus adaptation is expected

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