- we developed Salmonella Typhimurium strains of which the humoral response elicited in pigs can easily be differentiated from the humoral response, elicited by a wildtype fieldstrain.
- the use of these markerstrains as a vaccine in pigs would thus not interfere with existing Salmonella control programs in which the classification is based on the serological status of the herd
- vaccination with the novel strains leads to protection against a challenge with a highly virulent strain
- the novel strains can thus be used in the existing Salmonella control programs as a control measure
- moreover, vaccine strains can be developed with reduced recrudescence when pigs are in stress conditions
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